Research offers hope for patients affected by rare, hereditary metabolic diseases

New research offers potential benefits for those affected by the hereditary metabolic disease methylmalonic aciduria. By combining the results of multiple molecular analyses, scientists can better diagnose this rare and severe disease. In the future, an improved understanding of the disease might also improve treatment options. Methylmalonic aciduria (MMA) is a metabolic disorder that affects … Read more

Novel papillomaviruses identified in Malayan and Chinese pangolins

Papillomaviruses are non-enveloped, double-stranded DNA (dsDNA) viruses with a circular genome. Infection with these viruses can lead to several clinical symptoms ranging from subclinical, cutaneous, and mucosal warts to cancerous lesions in vertebrate hosts. A new study published in the journal Biology Letters identifies two novel lineages of papillomaviruses by mining the genome data of … Read more

AI tool promises to accelerate the development of gene therapies on a large scale

An artificial intelligence (AI) program may enable the first simple production of customizable proteins called zinc fingers to treat diseases by turning genes on and off. The researchers at NYU Grossman School of Medicine and the University of Toronto who designed the tool say it promises to accelerate the development of gene therapies on a … Read more

Study identifies the DNA roots of resistance to targeted cancer therapy

A new clinical and preclinical study from the UCLA Jonsson Comprehensive Cancer Center identifies the DNA roots of resistance to targeted cancer therapy, providing a possible strategy to address a vexing issue in cancer therapeutics. Results are published online ahead of print in Cancer Discovery, a journal of the American Association for Cancer Research. We … Read more

Study shows improved host health by modulating intestinal microbiota

In a recent study published in Gastroenterologyresearchers presented intestinal microbiota modulation as a probable therapeutic option for diseases such as Crohn’s disease (CD). Study: Modulating the Microbiome for Disease Treatment. Image Credit: Emily frost/Shutterstock Background Studies have reported that dysbiosis or imbalance in the intestinal microbiome could promote degenerative disorders, including diabetes, obesity, cardiovascular disease, … Read more

Scientists use next-generation protein degradation technology to study CTCF’s role in transcription

CTCF is a critical protein known to play various roles in key biological processes such as transcription. Scientists at St. Jude Children’s Research Hospital used a next-generation protein degradation technology to study CTCF. Their work revealed the superiority of the approach in addition to providing functional insights into how CTCF regulates transcription. The study, published … Read more

New method analyzes long-range interactions in the interactome

Researchers at the Josep Carreras Leukemia Research Institute have developed a method to analyze long-range interactions in the DNA – the interactome – from a very low amount of starting material. The method, named liCHi-C, opens the door to study the interactome of patient-derived samples instead of in vitro models for the first time and … Read more

Cryo-electron microscopy reveals detailed blueprint of viral genome replication machinery

RNA viruses, such as the coronavirus that causes COVID-19, are in a life-and-death race the moment they infect a cell. These viruses have only minutes to establish their replication machinery inside the host cell before the genetic instructions contained in their vulnerable RNA genomes – which are more fragile than DNA – would otherwise be … Read more

Targeting the newly discovered signaling pathway could boost the potency of cancer therapeutics

Cells zealously protect the integrity of their genomes, because damage can lead to cancer or cell death. The genome -; a cell’s complete set of DNA -; is most vulnerable while it is being duplicated before a cell divides. Cancer cells are constantly dividing, so their genomes are constantly in jeopardy. Researchers at Washington University … Read more

Study uncovers protein that acts as a brake for DNA replication

A protein that prepares DNA for replication also prevents the replication process from running out of control, according to a new study by Weill Cornell Medicine researchers. The work, published Jan. 5 in Molecular Cellsolves a mystery that has long puzzled biologists. The cells of humans and all other higher organisms use a complex system … Read more