Researchers identify an unexpected driver of cancer immunotherapy resistance

A research team from the LKS Faculty of Medicine, the University of Hong Kong (HKUMed) has identified an unexpected driver of cancer immunotherapy resistance: the harmful effect of chronic Type I Interferon signaling on tumor-killing CD8+ T cells. These findings provided new insights into the development of exhausted CD8+ T cells, which no longer effectively … Read more

Myanmar opium cultivation surged 33 percent amid violence, UN finds

Production of opium in Myanmar has flourished since the military’s seizure of power, with the cultivation of poppies up by a third in the past year, according to a United Nations’ report released on Thursday. Key points: The UN says virtually all the heroin seized in Australia originates in Myanmar It estimates the overall value … Read more

UK oncologists and cardiologists collaborate to prevent chemo-induced cardiomyopathy in cancer patients

Ever since she was 12 years old, Barbie Johnson has been a Kentucky girl at heart. Raised in the bluegrass, Barbie has worked at UK HealthCare for 18 years, first in gynecologic oncology and now in surgery scheduling. But she had no idea that while working with patients she would eventually become one herself. In … Read more

Kiwi man’s drug convictions see him kicked out of Australia

Phillip Rewha has lost an appeal to be deported from Australia under its 501 policy. Photo / Australian Border Force A Kiwi busted growing cannabis in his Perth home and found in possession of a plethora of drugs and paraphernalia has lost an appeal to be booted out of Australia under its 501 policy. Phillip … Read more

Using artificial human skin to block invasive growth in a skin cancer model

By using artificial human skin, a research group from the University of Copenhagen managed to block invasive growth in a skin cancer model. The study has been published in Science Signaling and looks at what actually happens when a cell turns into a cancer cell. We have been studying one of the cells’ signaling pathways, … Read more

Researchers report on a genome-wide reconstruction of human microbes to develop personalized therapies

In a recent study published in Nature Biotechnologyresearchers reported on AGORA2, an expansion of their previously published resource, AGORA, both resources of genomewide metabolic reconstructions of human intestinal microbes. Study: Genome-scale metabolic reconstruction of 7,302 human microorganisms for personalized medicine. Image Credit: nobeastsofierce/Shutterstock Human intestinal microbes synthesize biological metabolites, including neurotransmitters, hormones, and short-chain fatty … Read more

Targeting the newly discovered signaling pathway could boost the potency of cancer therapeutics

Cells zealously protect the integrity of their genomes, because damage can lead to cancer or cell death. The genome -; a cell’s complete set of DNA -; is most vulnerable while it is being duplicated before a cell divides. Cancer cells are constantly dividing, so their genomes are constantly in jeopardy. Researchers at Washington University … Read more

Researchers review the association between endogenous retrovirus reactivation and aging

In a recent review published in Cellresearchers explored the role of endogenous retrovirus (ERV) reactivation in the aging process. Study: Is aging a “retro” perspective event? Image Credit: BLACKDAY/Shutterstock ERVs are reported to be viral remnants of infections among primates that transform into stable genetic components at the boundary between own cell-deoxyribonucleic acid (DNA) and … Read more

George Marrogi and girlfriend Antonietta Mannella pleaded guilty to running a drug syndicate from jail

Inside one of Australia’s most secure prisons, George Marrogi would make up to 20 calls a day to his law firm — or so the guards inside thought. Key points: George Marrogi and girlfriend Antonietta Mannella pleaded guilty to high-level drug trafficking and importation The court heard the pair spoke in code when arranging the … Read more

TGA declares widely used antibiotic amoxicillin ‘scarce’ as stocks drop to record lows

Emergency compounding provisions for the oral antibiotic medication amoxicillin are in place across the country as Australia’s regulatory body for medicines declares the drug as “scarce”. Key points: The TGA has declared most stocks of the antibiotic amoxicillin as scarce Compounding chemists ramp up production amid scarcity protocols A pharmacist says amoxicillin compounding requests are … Read more