Understanding endemic and novel zoonotic spillovers from rodent trapping studies

The global impact of novel zoonotic pathogen spillovers has been highlighted through the ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the rapid outbreak of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus. In the past, similar effects were recorded during the HIV/AIDs and Spanish Influenza pandemics. Study: Rodent trapping studies as an overlooked information … Read more

New study evaluates post-COVID symptoms persistent for up to two years in non-hospitalized patients

In a recent study published in the Journal of Clinical Medicine, researchers followed up for two years with non-hospitalized post-coronavirus disease 2019 (COVID-19) patients in France and determined when they returned to work. These patients had persistent symptoms, with some incapacitating symptoms lasting as long as 22 months in a few cases, which prevented them … Read more

Researchers identify potent pan-sarbecovirus antibodies from non-human primates vaccinated with an AS03 adjuvanted subunit SARS-CoV-2 vaccine

In a recent study posted to the bioRxiv* preprint server, researchers assessed the effectiveness of pan-sarbecovirus-neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Study: Extremely potent pan-sarbecovirus neutralizing antibodies generated by immunization of macaques with an AS03-adjuvanted monovalent subunit vaccine against SARS-CoV-2. Image Credit: peterschreiber.media/Shutterstock Background Within the past two decades, the zoonotic … Read more

Is attention-deficit hyperactivity disorder a useful predictor of internalizing problems?

In a recent study published in Scientific Reportsresearchers assessed the importance of attention-deficit hyperactivity disorder (ADHD) features as a predictor of internalizing problems. Study: Attention-deficit hyperactivity disorder traits are a more important predictor of internalizing problems than autistic traits. Image Credit: StepanPopov/Shutterstock Autism spectrum disorder (ASD) is described as social-communication difficulties and repetitive and restrictive … Read more

Researchers identify a specific neural mechanism behind remembering emotional events

Most people remember emotional events, like their wedding day, very clearly, but researchers are not sure how the human brain prioritizes emotional events in memory. In a study published January 16, 2023, by Nature Human Behaviour, Joshua Jacobs, associate professor of biomedical engineering at Columbia Engineering, and his team identified a specific neural mechanism in … Read more

Immunological interactions between asthma, obesity, and the microbiota

Asthma and obesity are common inflammatory diseases that are mediated by specific immunological features. For example, asthma is associated with Th2 response, while obesity is with the Th1/Th17 profile. When these immunological features are combined, more severe asthmatic reactions occur with greater frequency. Recently, alterations in the immunological features, in relation to obesity and asthma, … Read more

Tight transmission bottlenecks may limit the evolution of SARS-CoV-2 variants

A study published in Nature Communications describes that tight transmission bottlenecks restrict the evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the transmission chain. SARS-CoV-2 is the causative pathogen of the coronavirus disease 2019 (COVID-19) pandemic. Study: Rapid transmission and tight bottlenecks constrain the evolution of highly transmissible SARS-CoV-2 variants. Image Credit: Lightspring/Shutterstock … Read more

The loss of epigenetic information accelerates the aging process

The basis of life depends on the complex interplay of information stored in the epigenome, genome, and cellular machinery. This is thought to be the software and biological hardware. However, whether a breakdown in the software or hardware causes aging is not yet known. In the 1950s, Szilard and Medawar independently proposed that aging results … Read more

Scientists use paleogenomics to trace 10,000 years of human immune system evolution

Scientists from the Institut Pasteur, Université Paris Cité, the CNRS and the Collège de France have used paleogenomics to trace 10,000 years of human immune system evolution. They analyzed the genomes of more than 2,800 individuals who lived in Europe over the past ten millennia. They were able to date the increase in frequency of … Read more

Deletions in the antigenic regions in SARS-CoV-2 increase transmission and immune evasion ability

A recent study published in the journal Scientific Reports examined the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) whole genome data to determine the deletion mutations around the spike protein region associated with increased transmission of the virus and identified an increase in the deletion-prone spike protein regions indicating an evolution strategy for immune escape. … Read more