Children’s immune systems do not develop ‘adaptive’ memory to protect against second time SARS-CoV-2 infection

Children have largely avoided severe COVID-19 symptoms because they have a strong initial ‘innate’ immune reaction that quickly defeats the virus. And now, researchers led by scientists at the Garvan Institute of Medical Research have uncovered what this might mean for the immune system. Unlike those of adults, children’s immune systems do not remember the … Read more

Maternal and perinatal outcomes of women infected with SARS-CoV-2 during the Omicron wave in Italy

In a recent study published in the Clinical Microbiology and Infectionresearchers assessed the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination on pregnant women during the Omicron wave. Study: Vaccination against SARS-CoV-2 in pregnancy during the Omicron wave: the prospective cohort study of the Italian obstetric surveillance system. Image Credit: GolF2532/Shutterstock Background During … Read more

Targeting the newly discovered signaling pathway could boost the potency of cancer therapeutics

Cells zealously protect the integrity of their genomes, because damage can lead to cancer or cell death. The genome -; a cell’s complete set of DNA -; is most vulnerable while it is being duplicated before a cell divides. Cancer cells are constantly dividing, so their genomes are constantly in jeopardy. Researchers at Washington University … Read more

Scientists demonstrate how microbiome and feeding patterns impact circadian rhythms in the gut

A study published in the journal PNAS reveals that the gut microbiome stabilizes the synchronization between gut and brain circadian rhythms. Study: The microbiome stabilizes circadian rhythms in the gut. Image Credit: Vovantarakan/Shutterstock Background The gut microbiome is a community of microorganisms that reside in the human/animal digestive tract. It plays a vital role in … Read more

Mutations may underlie how the most aggressive lymphomas arise and resist therapies

The key to understanding how the most aggressive lymphomas arise and resist current therapies may lie in mutations that disrupt a critical natural selection process among antibody-producing B cells, according to a multi-institutional preclinical study led by Weill Cornell Medicine investigators. Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma, with … Read more

MedUni Vienna researchers identify specific immune response to Epstein-Barr virus

Medical science has not yet been able to explain why the Epstein-Barr virus triggers infectious mononucleosis (IM) in some people with initial infections and not in others. But now, a research team led by Elisabeth Puchhammer-Stöckl, head of the Center for Virology at MedUni Vienna, has identified a specific immune response to the virus as … Read more

Researchers find that study results converge on a consistent relationship between antibody levels and protection from COVID-19

In a recent study published in Emerging Infectious Diseasesresearchers described the factors associated with protection, protection thresholds, and immunobridging in coronavirus disease 2019 (COVID-19) patients. Study: Correlates of Protection, Thresholds of Protection, and Immunobridging among Persons with SARS-CoV-2 Infection. Image Credit: ktsdesign/Shutterstock Background Forecasting the future efficacy of vaccines to determine the link between protection … Read more

Epitope mapping reveals the humoral responses against the main SARS-CoV-2 structural proteins in infected patients from Africa

In a recent article published in Scientific Reports, researchers performed immunoglobulin (Ig)M and IgG epitope mapping against 487 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) peptides. These peptides encompassed four main structural proteins of SARS-CoV-2, viz., spike (S) glycoprotein, envelope (E), nucleocapsid (N), and membrane (M) proteins. Study: Linear epitope mapping of the humoral response … Read more

The diverse mechanisms by which galectins can regulate adaptive and innate immune responses

In a recent review published in Nature Reviews Immunologyresearchers explored ways galectins can impact immunity and discussed the opportunities and challenges in the field. Study: The role of galectins in immunity and infection. Image Credit: Maryna Olyak/ Background Galectins comprise carbohydrate or glycan-binding proteins that are expressed by several types of cells and bind with … Read more

What is the effectiveness of a multivalent exosome-based COVID-19 vaccine?

In a recent study posted to the bioRxiv* preprint server, researchers assessed the effectiveness of a multivalent exosome-based coronavirus disease 2019 (COVID-19) vaccine. Study: Exosome based multivalent vaccine: achieving potent immunization, broaden reactivity and T cell response with nanograms of proteins without any adjuvant. Image Credit: Ground Picture/Shutterstock Background Despite the evident usefulness of COVID-19 … Read more